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A wide range of in vivo studies in miceratsdogsand monkeysand in vitro studies using ratmonkeyand human hepatocytes suggest that peroxisome proliferation in the liver is a rat-specific findingHoweverother effectsincluding increased liver weights and APTToccurred in dogs and monkeys at doses giving Css trough levels of the parent terbinafine 2-3x those seen in humans at the MRHDHigher doses were not tested.
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In plasmaterbinafine is99bound to plasma proteins Buy coreg 25 mg and there are no specific binding sitesAt steady-statein comparison to a single dosethe peak concentration of terbinafine is 25higher and plasma AUC increases by a factor of 2.5the increase in plasma AUC is consistent with an effective half-life of.
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