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There is an enhanced corticosteroid effect in patients with hypothyroidism and in those with cirrhosis.

Corticosteroids should be used with caution in patients with nonspecific ulcerative colitis if there is a probability of impending perforationabscessor other pyogenic infectionCorticosteroids should also be used cautiously in patients with diverticulitisfresh intestinal anastomosesactive or latent peptic ulcerrenal insufficiencyhypertensionosteoporosisand myasthenia gravis.

Children who are on immunosuppressant drugs are more susceptible to infections than healthy childrenChicken pox and measlesfor examplecan have a more serious or even fatal course in children on immunosuppressant corticosteroidsIn such childrenor in adults who have not had these diseasesparticular care should be taken to avoid exposureIf exposedtherapy with varicella zoster immune globulinVZIGor pooled intravenous immunoglobulinIVIGas appropriatemay be indicatedIf chicken pox developstreatment with antiviral agents may be considered.

When administered concurrentlythe following drugs may interact with adrenal corticosteroids.

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