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When prochlorperazine is used with cancer chemotherapeutic drugs.vomiting as a sign of the toxicity of these agents may be obscured by the anti-emetic effect of prochlorperazine.

A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia.muscle rigidity.altered mental status and evidence of autonomic instability (irregular pulse or blood pressure.tachycardia.diaphoresis and cardiac dysrhythmias).

Before having surgery.tell your doctor or dentist about all the products you use (including prescription drugs.nonprescription drugs.and herbal products).

Adverse reactions with different phenothiazines vary in type.frequency and mechanism of occurrence.i.e..some are dose-related.while others involve individual patient sensitivity. Some adverse reactions may be more likely to occur.or occur with greater intensity.in patients with special medical problems.e.g..patients with mitral insufficiency or pheochromocytoma have experienced severe hypotension following recommended doses of certain phenothiazines.

Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. However.the syndrome can develop.although much less commonly.after relatively brief treatment periods at low doses.

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